Our genomics laboratory delivers advanced blood group genotyping using next‑generation sequencing (NGS) and targeted Sanger sequencing to provide unparalleled precision in transfusion support. With a specialized focus on the RH blood group system (RHD and RHCE), our team applies internationally recognized scientific expertise to solve complex serologic challenges, guide donor‑patient matching, and improve transfusion outcomes.
When Is RHD and RHCE Genotyping Useful?
Determining Rh immune globulin (RhIG) eligibility
- Clarifying D status in patients with discrepant or weak serologic results
Evaluation of weak D or partial D phenotypes
- Differentiating patients who can be managed as Rh positive from those who should be treated as Rh negative
Transfusion management
- Determining whether Rh-negative red blood cell units are required
Obstetric patients
- Supporting safe prenatal and perinatal RhIG management
Precision transfusion for patients who are chronically transfused
- Identify partial antigen expression and alloimmunization risk
Complex Rh typing cases
- Resolving serologic discrepancies or unexplained Rh antibodies
RH Blood Group Expertise
Our laboratory is the leader in RH genotyping, offering deep specialization in the complex genetics of the RHD and RHCE loci. Because RH variants play a major role in alloimmunization risk, hemolytic disease of the fetus/newborn (HDFN), and complex transfusion requirements, our experts provide clinically meaningful interpretation that supports safer, more informed transfusion decisions.
- Expertise in RHD zygosity, partial D, weak D, and RHCE allele variants
- Advanced resolution of serologic discrepancies
- Consultation available for challenging clinical scenarios
Our Technology: State‑of‑the‑Art Genomic Testing
Next‑Generation Sequencing (NGS)
- Full gene sequencing for RHD and RHCE
- High‑resolution detection of single nucleotide variants, indels, hybrid alleles, and gene conversions
- Phasing for most accurate phenotype prediction
- Scalable platform suitable for both donor and patient testing
Sanger Sequencing
- Targeted sequencing of any blood group gene
- Ideal for variant confirmation
Rare & Novel Variant Detection
With advanced NGS and confirmatory sequencing, our laboratory identifies rare, low‑frequency, and novel blood group variants that may be missed by traditional genotyping or serologic testing. This capability ensures more accurate donor matching and improved safety for patients with highly alloimmunized or complex transfusion profiles.
Why Choose Our Laboratory?
- Internationally recognized expertise in RH genotyping
- Industry‑leading accuracy and interpretation
- Advanced detection of rare and novel alleles
- Fast turnaround times
- Robust quality systems and regulatory compliance
- Personalized support for hospitals, IRLs, donor centers, and research programs
RHCE Allele Reference Table
The RHCE Table is curated and maintained by NYBCe’s internationally recognized experts in the RH blood group system.