Our genomics laboratory delivers advanced blood group genotyping using next‑generation sequencing (NGS) and targeted Sanger sequencing to provide unparalleled precision in transfusion support. With a specialized focus on the RH blood group system (RHD and RHCE), our team applies internationally recognized scientific expertise to solve complex serologic challenges, guide donor‑patient matching, and improve transfusion outcomes.
What is RH Genotyping?
RH genotyping analyzes the RHD and RHCE genes to identify coding variants and determine the specific alleles an individual carries. This genetic information allows for an accurate prediction of the RH phenotype. By directly characterizing weak or partial antigen expression and clarifying alloimmunization risk, RH genotyping provides a more complete and reliable assessment of the RH blood group system than serologic testing alone.
Applications of RH Genotyping:
- Supporting patients receiving chronic transfusions (sickle cell disease, thalassemia)
- Clarifying unexplained antibodies in the RH blood group system
- Distinguishing allo- vs auto antibody in the RH blood group system
- Resolving typing discrepancies or discordances for RH antigens
- Determining alloimmunization risk
- Screening donors for RH genotypes needed for patients with complex RH antibodies
RHD Genotyping
Learn more about RHD Genotyping
RHCE Genotyping
Resolve typing discrepancies, determine weak or partial RhCE antigen expression, explain unusual antibodies, and clarify alloimmunization risk.
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RH Blood Group Expertise
Our laboratory is the leader in RH genotyping, offering deep specialization in the complex genetics of the RHD and RHCE loci. Because RH variants play a major role in alloimmunization risk, hemolytic disease of the fetus/newborn (HDFN), and complex transfusion requirements, our experts provide clinically meaningful interpretation that supports safer, more informed transfusion decisions.
- Expertise in RHD zygosity, partial D, weak D, and RHCE allele variants
- Advanced resolution of serologic discrepancies
- Consultation available for challenging clinical scenarios
Our Technology: State‑of‑the‑Art Genomic Testing
Next‑Generation Sequencing (NGS)
- Full gene sequencing for RHD and RHCE
- High‑resolution detection of single nucleotide variants, indels, hybrid alleles, and gene conversions
- Phasing for most accurate phenotype prediction
- Scalable platform suitable for both donor and patient testing
Sanger Sequencing
- Targeted sequencing of any blood group gene
- Ideal for variant confirmation
Rare & Novel Variant Detection
With advanced NGS and confirmatory sequencing, our laboratory identifies rare, low‑frequency, and novel blood group variants that may be missed by traditional genotyping or serologic testing. This capability ensures more accurate donor matching and improved safety for patients with highly alloimmunized or complex transfusion profiles.
Why Choose Our Laboratory?
- Internationally recognized expertise in RH genotyping
- Industry‑leading accuracy and interpretation
- Advanced detection of rare and novel alleles
- Fast turnaround times
- Robust quality systems and regulatory compliance
- Personalized support for hospitals, IRLs, donor centers, and research programs
RHCE Allele Reference Table
The RHCE Table is curated and maintained by NYBCe’s internationally recognized experts in the RH blood group system.