RHCE genotyping analyzes the RHCE gene to detect and characterize coding variants that influence Rh antigen expression. These variant alleles may produce:
- Weak or partial expression of the common Rh antigens (C, c, E, e)
- Expression of low‑prevalence antigens such as CW, V, or Goa
- An RhCE protein that lacks a high‑prevalence antigen (for example, hrB‑ or Hr‑)
RHCE genotyping addresses the limitations of serologic testing and provides clearer insight into variant antigen expression and associated alloimmunization risk.
When should RHCE genotyping be ordered?
- Resolve typing discrepancies of common RH antigens (C, c, E, e)
- Clarify complex or unexplained RH antibodies
- Distinguish auto- vs alloantibodies (ex: anti-C in C+ individual)
- Determine alloimmunization risk
RHD Genotyping
Identify weak and partial D expression to determine the most accurate transfusion recommendations and Rh immune globulin decisions.
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RH Genotyping
Analyze RHD and RHCE genes to gain insight into antigen expression and alloimmunization risk.
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RHCE Allele Table
The NYBCe RHCE Table is a uniquely comprehensive and continuously updated resource that documents RHCE alleles associated with clinically significant antigen expression and serologic findings. Each entry includes associated phenotypes, linkage relationships, and antibody production information when available.