Quick Lessons in Immunohematology have been created to provide information on a variety of immunohematology topics in an easy-to-digest format. Whether you are learning the fundamentals of blood banking, or would like a refresher on a specific subject, feel free to browse and download our current selection of Quick Lessons.
Alloimmunization & Sickle Cell Disease
- Discuss alloimmunization rates for Sickle Cell Disease (SCD) patients compared to other groups of patients.
- Describe the benefits and challenges of antigen-matching protocols for SCD patients.
- Explain how a SCD patient might develop alloantibodies to an antigen present on his/her cells.
Antibody to a High Prevalence Antigen
- Describe characteristic serologic reactivity of an antibody to a high prevalence antigen.
- Explain how testing phenotype-matched RBCs differentiates multiple common antibodies from an antibody to a high prevalence antigen.
- Discuss how the following factors provide clues in the identification of an antibody to a high prevalence antigen: patient ethnicity, testing treated reagent RBCs, antigen typing the patient’s cells, testing rare cells.
- Describe the interference of anti-CD38 monoclonal antibody in blood bank tests.
- List ways to mitigate the serologic interference of anti-CD38.
- Discuss transfusion strategies for patients receiving anti-CD38 therapy.
- Discuss Rh haplotypes, using both Fisher-Race and Weiner nomenclature, and explain how to determine f status using other Rh typings.
- Compare and contrast weak D and partial D.
- List unique circumstances in which an antibody might have Rh specificity.
Blood Bank Methodologies
- Describe tube testing, gel testing and solid phase testing in the blood bank.
- Compare and contrast the three methodologies.
- List advantages and disadvantages of each methodology.
Elution & Eluates
- List several reasons why an individual might have a positive direct antiglobulin test (DAT).
- Explain the process of preparing an acid eluate.
- Discuss how the reactivity of an eluate can explain the cause of a positive DAT.
- Name three types of antigens expressed on the surface of platelets.
- Discuss immune platelet refractoriness, including antibodies that cause refractoriness and transfusion options.
- Describe two conditions caused by antibodies to human platelet antigens (HPA).
- Discuss the most common reasons titration is used in the blood bank.
- Discuss the reactivity known as HTLA.
- Interpret titer results.